Journal of Engineering Physics and Thermophysics
is a translation of Inzhenerno-fizicheskii Zhurnal,
a publication of the Academic Scientific Complex
"A. V. Luikov Heat and Mass Transfer Institute"
of the National Academy of Sciences of Belarus
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STATEMENT OF THE PROBLEM OF OPTIMIZATION AND CONTROL
OF TISSUE TEMPERATURE DISTRIBUTION IN LOCAL HYPERTHERMIA
OF MALIGNANT TUMORS
V. G. Litvinov, A. D. Panteleev, V. L. Sigal,
Z. P. Shul'man, and T. E. Shumakova
UDC 517.946:612.57
We consider a model of thermal processes in treatment by
local hyperthermia. The model is based on the classical nonlinear
biothermal equation. We formulated a problem of optimization consisting
of maximization of the mortality function of tumor cells and finding
a control for which the temperature distribution in the tumor maximizes
the therapeutic effect, while the injury function of healthy tissue
is small.
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JEPTER74920199615
JEPTER7492015